If you assign patient the drug prednisone as a therapy in cases of severe osteoporosis, developed peptic ulcer disease, poliomyelitis and myopathies, you need to clearly assess the severity of the disease and to determine the time necessary for the introduction of this drug. First, introduce the patient an initial high dose of prednisone, determined individually in accordance with the effectiveness of therapy, readings and General condition of the patient. It does not exceed the maximum daily dose of prednisolone 200 milligrams, in most cases, the allowable dose for adults is 5 to 60 mg/day.
For children, the dose of prednisone set on the basis of body weight, the total amount of the used medication should not exceed 0.14 mg/kg of body weight of the child per day and the daily dose fall in equal installments in three or four divided doses, preferably after equal intervals of time. In plasma the maximum concentration of prednisolone is achieved through two hours after entering, and after 3.5 hours the half-life, so maintain a desired concentration of the drug in the patient's blood. Recommendations on how to reduce prednisolone, affect already the second week of use, as taking prednisone tablets or injection not stop abruptly.
First, to the patient after the cessation of prednisolone therapy did not develop renal failure, after a week of injection reduce dose to 20% or more. Then, by the end of the second week of using this glucocorticoid drug, to reduce the dose of prednisone per day for 2-3 milligrams. So daily for 7-10 days enter the patient the drug in smaller amounts until the complete cessation of the use of prednisolone.
Secondly, in the case where the patient requires long-term treatment with glucocorticoid drug, dose reduction of prednisolone in the second week of its use will only decrease levels of drug in the blood plasma. If necessary, prolonged therapy with prednisolone for children under the age of fourteen, realize intermittent injection – in the first three days of therapy to enter the patient's full daily doses of prednisone, then take a break to use the drug for four days, and then continue to enter the medication, but in a reduced dose.
Advice 2: How to drink on prednisone
Prednisone is a glucocorticosteroid drug, antiallergic and anti-inflammatory properties. Medication is prescribed in a number of different severity and origin of diseases.
Prednisone prescribed for allergic, autoimmune diseases (scleroderma, rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis etc.), diseases of the joints, skin (eczema, psoriasis, various types of dermatitis, etc.), cerebral edema, some diseases of the eyes, lungs, kidneys, gastrointestinal tract. In organ transplants the drug is indicated for the prevention of graft rejection. In Oncology, prednisone taken during chemotherapy to eliminate nausea and vomiting.
One tablet contains 5 mg of active ingredient. In the acute period of the disease drink 4-6 tablets a day. After you have stabilized the daily dose reduce to 1-2 tablets. Take the medicine once daily, preferably at 6-8 o'clock in the morning.
In severe situations, the doctor may prescribe up to 100 mg (20 tablets) of prednisone per day. In this case, divide the daily dose into 2-4 reception.
In the acute phase of the disease children prednisolone at a dose of 1-2 mg/kg of body weight. Dispense medication for 4-6 receptions. Maintenance dose (after the stabilization) three times lower than therapeutic.
Drink the pills during a meal or immediately after it. Wash down the medicine with a small amount of liquid.
Don't stop the drug abruptly, especially if treatment was prolonged. Reduce the dose gradually.
Prednisolone is incompatible with many medicines, including acetaminophen. Consult your doctor before starting treatment not to harm the body.
During treatment with prednisone can be side effects of varying severity. Of all deviations in health status is reported to the doctor. If you feel unwell do not always require withdrawal of the drug, sometimes a dose adjustment.