How does Analgin

Analgin is able to block cyclooxygenase, an enzyme involved in the synthesis of prostaglandins (a group of substances involved in the formation of painful and inflammatory processes). As a result, the synthesis process of the prostaglandins, arachidonic acid, bradikininov is slowing down pain impulses are blocked, the heat increases, body temperature decreases.

Analgin available in tablets, ampoules (solution for intramuscular and intravenous), suppositories rectal. Pills, suppositories of the medication are starting to act in 15-30 minutes after application. The maximum concentration in blood observed after an hour and a half after applying. The drug is injected will reach you in 10-20 minutes. The duration of "cold sores" - 4-8 hours. The ingestion of the active ingredient of the drug is 80-90% absorbed in the gastrointestinal tract, a small part of it binds to the blood protein, the major concentration is in the body in unbound form.
Metamizole sodium by itself has no pharmacological effect, the therapeutic effect develops after conversion by the liver into a metabolite.

How to apply "Analgin"

Analgin is used in rheumatism, fevers, acute respiratory diseases, with different pains (neuralgia, neuritis, myositis, radiculitis). The drug is usually prescribed at 250-500 mg two to three times a day. The maximum allowable single dose of 1 g daily – 3 g.

Intramuscularly or intravenously tool used in severe pain 250-500 ml three times a day. Children under one year of age the drug is prescribed in the form of intramuscular injections two or three times a day, at the rate of five to ten milligrams per kilogram of body weight. In adults "Analgin" in the form of rectal suppositories used in dosages of 300, 650,1000 mg. Rectal suppositories children prescribed, given the disease and age. For children from six months to a year are recommended candle 100 mg, children 1-3 years appoint candles 200 mg for children 3-7 years light candles 200-400 mg for children aged 8-14 years - 200-600 milligrams.
After drug administration rectal need to lie down for a while.

"Analgin" can have the following side effects: skin rash, leukopenia, skin rash, fever, headache, dizziness. The drug is contraindicated in diseases of the blood, inhibition of the function of the blood, during pregnancy and breastfeeding, in dysmenorrhea, liver, renal failure, aspirinbuy asthma, anaemia.