Advice 1: Clavulanic acid: action and properties

Clavulanic acid - a substance that interacts with a penicillinase. It includes part of the combined antimicrobial drugs or used in combination with beta-lactam antibiotics.
Clavulanic acid: action and properties

How does clavulanic acid



Clavulanic acid is a member of metabolical (enzymes and antifermental). It is an inhibitor of beta-lactamase enzymes and has antibacterial action. The substance structure is similar to the structure of the nucleus the nucleus of the penicillin molecule. However, in contrast, is tiazolidinovogo ring part clavulanic acid is included oxazolidinone ring.

Once inside clavulanic acid inhibits beta-lactamase produced as a result of gram-negative and other microorganisms. The mechanism of action of the substance is as follows: clavulanic acid penetrates through the membrane of the bacterial cells and inactivates enzymes within these cells and on their boundaries. The process of inhibiting beta-lactamase is often irreversible. As a result, the microorganisms are unable to develop resistance to commonly used antibiotics.

How to use drugs with clavulanic acid



Klavulanova acid is administered concurrently with "Amoxicillin" or "Tikarcillina" for the treatment of infectious-inflammatory diseases caused by sensitive to the combination of microorganisms. The drug dosage is individual and determined by the doctor depending on the patient's age, indications, and dosage forms. Intravenous clavulanic acid used with caution in patients with severe violations of the functional state of the liver. The appearance of urticaria or erythematous rash, the medication should be stopped.

Clavulanic acid is contraindicated in individual intolerance. During pregnancy allowed the use of this drug "Amoxicillin" or "Tikarcillina" only for health reasons. Lactation to apply the medicine not recommended. Adverse effects of clavulanic acid include: dyspepsia, cholestatic jaundice, violation of the functional state of the liver, hepatitis, pseudomembranous colitis, candidiasis, allergic reactions (erythema multiforme, angioedema, exfoliative dermatitis, urticaria, anaphylactic shock).

The trade name of the drug with clavulanic acid "clavulanate Potassium + microcrystalline Cellulose". Combination medicines containing klavulanova acid: "AmbiCom", "Amoxiclav", "Amoxiclav, Quicktab", "Arlet", "Augmentin", "the store for help", "Warclaw", "Clamour", "Likev", "Anklav", "Anklav", "Fromentine", "Flemoklav)", "Ecoclub", "Timentin".

Advice 2 : How to drink folic acid during pregnancy

Folic acid, or vitamin B9, is involved in metabolic processes responsible for the formation of red blood cells and stimulates the digestive system. During pregnancy the need for it increases. Vitamin a deficiency may cause anemia, birth defects in the fetus, placental insufficiency, and sometimes even a miscarriage.
How to drink folic acid during pregnancy
Instruction
1
Vitamin B9 is involved in the formation of the neural tube of the fetus, and this process begins already in the third week of pregnancy. At this time the woman can even not guess about your situation, and folic acid deficiency will cause irreparable harm to the embryo. Therefore start taking vitamin C the first day of the menstrual cycle, but preferably 2-3 months before planned conception. This will allow you to compensate for the existing deficit and beneficial impact on your health. If the pregnancy is unplanned, but you decided to keep her, start taking folic acid from the first days of delay.
2
Three times a day drink one pill of folic acid. Up to 12 weeks of pregnancy is the minimum necessary dose of the drug. Even if you take the complex vitamins, which include folic acid, do not reduce dosage. Excess vitamin is excreted by the kidneys without any harm to the body, so you can drink it without fear.
3
After 12 weeks of pregnancywhen all organs and systems of the fetus are formed, the need for folic acid is reduced. Reduce the drug to one tablet a day.
4
If you have revealed anemia or placental insufficiency, increase the folic acid dosage to 2-3 pills a day. Drink it in the time of the meal or immediately after it.
5
Folic acid is absorbed in the intestines, so his work depends on the absorption of much needed vitamin. Every day, eat dairy products. They contain bifidobacteria and Lactobacillus, which improves digestion and normalizes the intestinal microflora.
Note
In infectious diseases, toxicosis of the first trimester, the disruption of the liver, stress dosage of folic acid may be increased.
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