Histamine is a mediator involved in the regulation of vital functions of the human body. Under normal conditions, this biogenic compound is inactive, but once the body gets the allergen into the blood immediately receives a huge amount of free histamine.

The principle of operation

Free histamine is increased activity: it expands the capillaries and lowers blood pressure, as a result, the blood stagnates and thickens, surrounding tissues swell, and smooth muscles and the bronchial muscles go into a state of spasm. In addition there is the reflex excitation of the adrenal medulla, and the result is the release of adrenaline, the constriction of arterioles and increased heart rate. Through the release of histamine increases the secretion of gastric juice.

A certain amount of the substance contained in the CNS, where it acts as a neurotransmitter. It is possible that some lipophilic antagonists of histamine, penetrating through the barrier protivogistaminnyh drugs that have a sedative effect due to a blocking effect on Central histamine receptors.

High concentration of histamine in the blood can cause anaphylactic shock in this case can only help a shot of adrenaline, because antihistamine drugs can only suppress the action of histamine receptors. In order not to become hostage to muscle spasm and asthma attack, it is necessary to take preventive measures and always have funds on hand from allergies, especially those who are inclined to this. This group of drugs blocks the histamine receptors and prevent the release of free histamine in the blood.

As histamine is used in medicine

Histamine is widely used in medicine for the treatment of various diseases. It can be purchased as white powder and in the form of 0.1% solution. Shown this drug in diseases such as sciatica, rheumatism, arthritis, and plexitis. Asthma and urticaria with an allergic nature, patient is prescribed a course of injections of histamine. As a result, the body becomes more resistant to this substance and the predisposition to allergies is reduced.

In connection with the ability of histamine to stimulate gastric secretion may be used to diagnose the state of the stomach. Oral administration of this drug no effect, it works with intradermal introduction, rubbed into the form of ointments or use during electrophoresis.