How to use "HEPA-Merz"
"HEPA-Merz" prescribed for acute, chronic liver disease, accompanied by hyperammonemia, and in latent and severe hepatic encephalopathy. The drug has hepatoprotective, detoxifying effect, normalizes protein metabolism, lowers the level of ammonia has a positive effect on the synthesis of insulin. The action of the active substance due to his involvement in the formation of urea. Analog of the drug the active substance is Ornetzeder", analogs in the pharmacological group include: "Hepabene", "Gaafar", "Deepana", "Karsil", "Maksar," "Silimar", "Essentiale N", "Essliver".
"HEPA-Merz" is produced in the form of granules for preparation of solution. You must ingest 1-th packet 2-3 times a day after meals. Pre-granules dissolved in 200 ml of water. With the aim of intravenous drip infusion of 20 g of product dissolved in 500 ml of 5% glucose solution, physiological saline, ringer solution. In severe cases, allowed increasing the daily dosage up to 40 g. the Maximum infusion rate of 40 drops/min. At the appearance of nausea, vomiting it is necessary to reduce the rate of drug administration. Duration of treatment determined by the doctor. It depends on the patient's condition and the dynamics of the concentration of ammonia in the blood. The therapy can be repeated every 2-3 months.
Contraindications, side effects of the drug "HEPA-Merz"
"HEPA-Merz" is contraindicated in severe renal failure when creatinine level above 3 mg/100 ml, hypersensitivity to components, in the period of lactation. With caution the drug is used during pregnancy. "HEPA-Merz" is incompatible with "Rifampicin", "Penicillin", "Diazepam", "Meprobamate", "Ethionamide", "Phenobarbital", vitamin K.
Adverse effects "HEPA-Merz" include allergic reactions, vomiting, nausea. In case of accidental overdose, adverse reactions increase. In this case it is required gastric lavage, administration of activated charcoal. Patients with a diagnosis of "hepatic encephalopathy" should be very careful when driving and occupation of other potentially hazardous activities, the performance of which requires increased concentration of attention and quickness of psychomotor reactions. Shelf life 5 years. "HEPA-Merz" is stored in a place inaccessible to children at temperature not exceeding 25C. The drug is available without a prescription.
