The symptoms and treatment of the syndrome of rigid person
The main manifestations of the syndrome of rigid person include: increasing muscle tension (rigidity) and muscle spasms. The process starts with the core muscles in a few months it is distributed to the muscles of the proximal extremities. The disease is an increase in the excitability of the alpha motoneurons of the anterior horns of the spinal cord, however, the causes of this condition is still not established.
Treatment of stiffness of the muscles in the syndrome of rigid person is symptomatic. The patient is prescribed GABAergic funds: benzodiazepines (Clonazepam, Diazepam and Baclofen, affect neuromuscular transmission. Drugs block the increased activity of spinal motor neurons and reduces the severity reflex, spontaneous muscle spasms and rigidity.
How to take the drugs for the treatment of the syndrome of rigid person
The most commonly used Diazepam (Sibazon" "Relanium"). It enhances GABAergic transmission and simultaneously inhibits noradrenergic transmission. The drug starts with the minimum dose (2.5 mg), it is taken 1-2 times a day. Then the daily amount gradually increased to achieve the desired effect of taking the drug for 3-4 times. The range of therapeutic doses depends on individual sensitivity of the patient and can vary from 10 to 200 mg per day.
Instead of "Diazepam", you can use "Clonazepam" in the amount of 2-10 mg/sut. The ineffectiveness of benzodiazepines prescribed "Baclofen (GABA agonist-receptor type). It is taken together with one of the benzodiazepines, or use as monotherapy. The daily dose increase gradually. The maximum number is 100-120 mg / day (3 admission).
The simultaneous administration of Baclofen and benzodiazepine therapeutic effect is achieved with lower doses than monotherapy. This reduces the risk of side effects. It is necessary to avoid abrupt withdrawal of medications because it is fraught with the deterioration and development of pronounced autonomic changes.
In case of intolerance or ineffectiveness of these agents administered drugs valproic acid: "Depakine" in a daily dose of 600-2000 mg, "Tiagabine at the dose of 4-12 mg / day or Vigabatrin in the daily amount of 1500 mg. These drugs also enhance GABAergic transmission. The use of antiadrenergic drugs ("Clonidine", "Tizanidine") gives less of a constant treatment effect. In severe cases, paraspinal muscles injected "botulinum toxin A".