Description and pharmacological action of the drug
"Egilok" – synthetic agent used, in particular, for the treatment of hypertension, prevention of migraine. The main active ingredient of this drug is metoprolol tartrate. "Egilok" available in tablets at a dosage of 0.025 g, 0.05 g and 0.1 g in packs of 20, 30, 60,100 tablets. In pill form is released and the drug "egilok Retard" – with the same active and excipients. In a pack of 30 tablets at a dosage of 0.05 g and 0.1 g
The drug is very rapidly and almost completely (95 percent) absorbed from the gastrointestinal tract. Its bioavailability is 50 percent. In the process of treatment biodostupnostthew is 70 percent. Meal by 20-40 percent increases the bioavailability of the drug. The active substance of egilona - metoprolol – biotransformiroetsa in the liver. Drug metabolites are not active farmacologiche. 95 percent of the active ingredients of the drug is excreted within 72 hours in urine. About 5 percent of metoprolol remain unchanged. In this form they are excreted.
Indications for use
"Egilok" is assigned to patients with arterial hypertension (especially people older than 60 years), using this drug alone or in combination therapy with other antihypertensive agents. Need an appointment "egilona" for secondary prevention of myocardial infarction, for the prevention of angina, disorders of heart rhythm – ventricular extrasystole, supraventricular arrhythmias, in hyperthyroidism. Prescribed drug for prevention of migraine. Also, "egilok" is used in ischemic heart disease,
"Egilok" is a cardioselective beta-blocker exerting anti-hypertensive effects that reduce heart rate, reduce angina severity and frequency of attacks, improves the physical condition of the patient. Also thanks to the action of "egilona" can significantly reduce the risk of recurrent myocardial infarction. Prevents the occurrence of migraine. By adhering to these instructions doses has no effect on the peripheral arteries and the smooth muscles of the bronchi.
The maximum effect of the drug manifests itself already an hour and a half after ingestion. About 5 percent of active substance excreted in the urine unchanged. The remainder of the drug biotransformiroetsa in the liver. Therefore, people with liver disease, disorders of its functions the necessary medical supervision and dose adjustment.
Method of application and doses
Dosage "egilona" is determined for every patient individually taking into account his state of health and the presence of accompanying factors. For example, when hypertension the initial dose is 50 mg per day in one or two doses. With no effect or insignificant results, it is recommended to increase the dosage, but not more than 200 mg per day. For patients suffering from angina pectoris, the recommended dose is 100-200 mg / day 1 or 2 times a day. Similar dose and supraventricular arrhythmias and extrasystole. The drug should be taken twice a day (morning and evening). 100-200 mg per day two times per day is the dosage with the purpose of prevention of secondary myocardial infarction, migraine attacks. Increase the dose indicated in the abstract, is not recommended.
Diabetic patients needed to control blood sugar levels.
When you assign "egilona" patients with liver and kidney medical supervision is necessary. This is necessary in connection with the ability of the drug to accumulate in the excretory organs.
Contraindications to the use of the drug
"Egilok" should not be administered to patients with sinus bradycardia with heart rate less than 60 beats per minute; AV-blockade second-or third-degree sinoatrial blockade; disorders peripheral krovoobrascheniya; hypotension (low blood pressure below 90-100 mm Hg. grade); high susceptibility components of the drug. In this case, it is necessary to replace the drug any other means with similar effect.
During the reception, "egilok" may cause high fatigue, drowsiness, dizziness, depression, insomnia, reduced concentration, nausea, vomiting, diarrhea, constipation, dry mouth, abdominal pain, cardiac failure. In rare cases, may experience visual disturbances, ringing in the ears, conjunctivitis, allergic reactions, reddening of the skin, alopecia, increased sweating, increase in body weight. But in most cases the drug is well tolerated.
"Egilok" can cause confusion, drowsiness, therefore it should be used with caution in people whose profession requires special attention.
During pregnancy, the use of agilika is possible only if the benefit to the mother outweighs the risk to the fetus. This requires the mandatory monitoring of the status of the fetus. After birth also need monitoring of the newborn to exclude arterial hypertension, respiratory depression, bradycardia, decrease in blood sugar levels. During pregnancy, "egilok" it is recommended to replace a similar drug, but more gentle action.
Shelf life and storage conditions
Shelf life – 3 years.
Store at temperature not exceeding 25oC in a dry place not accessible to children.