Newborns with FOP appear to be perfectly normal, apart from the defect of the skeleton is a wedge-shaped deformation of the fingers and toes. With 95% probability the disease is diagnosed by a curved inside big toes, in some cases there is a lack of joints. Another characteristic is pathology of the vertebrae of the cervical spine.

For diseases peculiar to a sharp aggravation, the specific causes of which remain unidentified. The most frequent subcutaneous seal from one to ten centimeters, the nature of which is difficult to determine. The formation of such seals is often caused by injuries or even minor bruises, and are usually accompanied by high temperature. For medicines no reaction occurs. In the initial stages the symptoms of FOP is often referred to Oncology, and trying to solve the problem by surgery that only provokes strong ossification of the tissues. The rapid progression of the disease eventually leads to disability and early death of the patient.

The symptoms of FOP originate from muscles of the head or back, often from okolomatocnah Department, gradually moving through the abdominal and femoral divisions to the periphery of the body. This does not affect the diaphragm, tongue, and near eye muscles. Not subject to ossification of the cardiac and smooth muscles.

FOP occurs with a frequency of 1 to 2 million people and is characterized by individuality, the unpredictability of the currents. Various studies in this area is still not possible to predict when and how to manifest the disease. Any recorded private progress of the disease be completely insolvent when they are trying to check on another patient. Currently there are no specific forms of prevention and treatment of FOP.

Promising is gene therapy. Actively developed blockers of gene mutations.