Lipase is an enzyme (enzyme) that breaks down triglyceride into glycerol and higher fatty acids. Normally, its content in the circulating blood are quite low. This enzyme in the human body produces a number of organs and tissues that allows us to distinguish the origin of gastric lipase, pancreatic lipase lungs, digestive juices, white blood cells etc.
Pancreatic lipase plays a major role in digestion of fats. The most important from a clinical point of view is an enzyme of the pancreas. The normal concentration of enzyme in the blood consider the interval of 0.2-1.5 units (less than 150 u/l). For the diagnosis of diseases is conducted quantitative determination of lipase in the blood with biochemical studies.
The increase in lipase
Since the main source of the enzyme is the pancreas, when the disease occurs a significant release of the enzyme into the bloodstream. When taking certain medications (heparin, narcotic analgesics, hypnotics of the barbituric number, indomethacin) is the increase in the enzyme level in the blood. Violation of metabolism in the body (diabetes, gout, obesity) leads to the identification of the enzyme at higher concentrations.
The increase in the concentration of lipase in the blood is determined in acute pancreatitis, exacerbation of chronic pancreatitis, when blockage of the pancreatic duct (stone, tumor). Determination of the activity of the enzyme is the most informative criterion for the diagnosis of acute pancreatitis. Prognosis is poor if the level of lipase in the blood increases by 10 times or more and not reduced to 3-fold excess of the norm over the next few days.
Increased activity of lipase is possible for injuries, wounds, surgeries, fractures, and acute renal failure. In these cases, the determination of lipase is not diagnostic, since the increase in enzyme activity is not specific.
Preparations for the research
To determine the activity of lipase seems to venous blood in the morning on an empty stomach in the treatment room of the medical institution. The day before analysis is recommended diet that excludes the consumption of fatty, hot and spicy food. On the day of the manipulation should not drink tea, coffee, drinks. You should avoid physical exertion, emotional overstimulation. In case of emergency blood from a vein for rent, regardless of the time of day and prior preparation.